SB 216763

• Catalog No.: S3442
• CAS Number: 280744-09-4
• M. F.: C19H12Cl2N2O2
• M. W.: 371.21678
• Purity: >98% (HPLC)

SYNONYMS

• IUPAC name: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
• IUPAC Traditional name: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione
• Synonyms: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

DATABASE IDS

• CAS Number: 280744-09-4
• MDL Number: MFCD09753369
• PubChem SID: 24278616

PROPERTIES

• Empirical Formula (Hill Notation): C19H12N2O2Cl2
• Purity: >98% (HPLC)
• Gene Information: human ... GSK3A(2931), GSK3B(2932)
• Apperance: orange
• Melting Point: 287-288.6 °C(lit.)
• Solubility: DMSO: soluble20 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.
SB 216763 is a potent and selective ATP-competitive inhibitor of the serine/threonine protein kinase glycogen synthase kinase-3 (GSK-3) α and β isozymes.
Legal Information
Sold for research purposes under agreement from Glaxo-Smith-Kline

Description (简体中文)

Biochem/physiol Actions
Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.
SB 216763 is a potent and selective ATP-competitive inhibitor of the serine/threonine protein kinase glycogen synthase kinase-3 (GSK-3) α and β isozymes.
Legal Information
Sold for research purposes under agreement from Glaxo-Smith-Kline