Dolastatin 15

• Catalog No.: D5566
• CAS Number: 123884-00-4
• M. F.: C45H68N6O9
• M. W.: 837.05622
• Purity: ≥95%

SYNONYMS

• IUPAC name: (2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl (2S)-1-[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-(dimethylamino)-3-methylbutanamido]-N,3-dimethylbutanamido]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate
• IUPAC Traditional name: (2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl (2S)-1-[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-(dimethylamino)-3-methylbutanamido]-N,3-dimethylbutanamido]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate
• Synonyms: (5S)-1-[(2S)-O-(N,N-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline

DATABASE IDS

• MDL Number: MFCD00236968
• CAS Number: 123884-00-4
• PubChem SID: 24893943

PROPERTIES

• Empirical Formula (Hill Notation): C45H68N6O9
• Purity: ≥95%
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Val-Val-NMe-Val-Pro-Pro-2-hydroxyisovaleryl-2-oxo-4-methoxy-5-benzyl-3-pyrroline
Application
An anti-neoplastic pseudopeptide originally isolated from the sea hare Dolabella auricularia. Reported to interact with tubulin and induce apoptosis. Potent inhibitor of the proliferation of murine and cancer cell lines as well as of hematopoietic progenitor cells.

Description (简体中文)

Amino Acid Sequence
Val-Val-NMe-Val-Pro-Pro-2-hydroxyisovaleryl-2-oxo-4-methoxy-5-benzyl-3-pyrroline
Application
An anti-neoplastic pseudopeptide originally isolated from the sea hare Dolabella auricularia. Reported to interact with tubulin and induce apoptosis. Potent inhibitor of the proliferation of murine and cancer cell lines as well as of hematopoietic progenitor cells.