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MDL 28170

Catalog No. M6690 Name Sigma Aldrich
CAS Number 88191-84-8 Website http://www.sigmaaldrich.com
M. F. C22H26N2O4 Telephone 1-800-521-8956
M. W. 382.45284 Fax
Purity ≥95% (HPLC) Email
Storage Chembase ID: 153732

SYNONYMS

IUPAC name
benzyl N-[(1S)-2-methyl-1-[(1-oxo-3-phenylpropan-2-yl)carbamoyl]propyl]carbamate
IUPAC Traditional name
benzyl N-[(1S)-2-methyl-1-[(1-oxo-3-phenylpropan-2-yl)carbamoyl]propyl]carbamate
Synonyms
Calpain Inhibitor III

DATABASE IDS

PubChem SID 24278565
CAS Number 88191-84-8
MDL Number MFCD00798796

PROPERTIES

Compostion Peptide Content, >90%
Empirical Formula (Hill Notation) C22H26N2O4
Purity ≥95% (HPLC)
Shipped in wet ice
Gene Information human ... CAPN1(823), CAPN2(824)
Solubility DMSO: soluble26 mg/mL
Solubility H2O: insoluble
Solubility methanol: soluble
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Amino Acid Sequence
Z-Val-Phe-al
Biochem/physiol Actions
MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.
Description (简体中文)
Amino Acid Sequence
Z-Val-Phe-al
Biochem/physiol Actions
MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.

REFERENCES