ABT-418 hydrochloride

• Catalog No.: A6476
• CAS Number: 147388-83-8
• M. F.: C9H15ClN2O
• M. W.: 202.6812
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole hydrochloride
• IUPAC Traditional name: 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole hydrochloride
• Synonyms: 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride

DATABASE IDS

• PubChem SID: 24724395
• MDL Number: MFCD11045960
• CAS Number: 147388-83-8

PROPERTIES

• Empirical Formula (Hill Notation): C9H14N2O · HCl
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: H2O: soluble15 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 2811 6.1/PG 2
• Risk Statements: 26/27/28
• Safety Statements: 7/9-22-28-36/37-45
• Storage Condition: desiccated
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.
Legal Information
Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.
Application
ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer’s disease.

Description (简体中文)

Biochem/physiol Actions
Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.
Legal Information
Subject to U.S. Patent No. 5409946 and sold under license from Abbott Laboratories.
Application
ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enhancing and anxiolytic-like activity 3- to 10-fold more potent than (-)-nicotine in rodents. ABT-418 hydrochloride has been used to study new therapeutic approaches for the treatment of Alzheimer’s disease.