TNP-470

• Catalog No.: T1455
• M. F.: C19H28ClNO6
• M. W.: 401.88172
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl N-(2-chloroacetyl)carbamate
• IUPAC Traditional name: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl N-(2-chloroacetyl)carbamate
• Synonyms: (Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester; NSC 642492; O-Chloracetyl-carbamoyl fumagillol; AGM-1470

DATABASE IDS

• MDL Number: MFCD00870281

PROPERTIES

• Empirical Formula (Hill Notation): C19H28ClNO6
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >15 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Other Notes
TNP-470 is hygroscopic.
Biochem/physiol Actions
TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.

Description (简体中文)

Other Notes
TNP-470 is hygroscopic.
Biochem/physiol Actions
TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.