Mithramycin A from Streptomyces plicatus

• Catalog No.: 69823
• CAS Number: 18378-89-7
• M. F.: C52H76O24
• M. W.: 1085.14544
• Purity: ~80% (HPLC)

SYNONYMS

• Title: 光辉霉素 A 来源于褶皱链霉菌
• IUPAC name: (2S,3S)-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-2-{[(2S,4R,5R,6R)-4-{[(2S,4R,5R,6R)-4-{[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-6-{[(2S,4R,5S,6R)-4-{[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-8,9-dihydroxy-7-methyl-1,2,3,4-tetrahydroanthracen-1-one
• IUPAC Traditional name: (2S,3S)-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-2-{[(2S,4R,5R,6R)-4-{[(2S,4R,5R,6R)-4-{[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-6-{[(2S,4R,5S,6R)-4-{[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-8,9-dihydroxy-7-methyl-3,4-dihydro-2H-anthracen-1-one
• Synonyms: 普卡霉素; 金霉酸; Plicamycin; Aureolic acid

DATABASE IDS

• PubChem SID: 24885983
• Beilstein Number: 5236667
• CAS Number: 18378-89-7
• MDL Number: MFCD00135618

PROPERTIES

• Empirical Formula (Hill Notation): C52H76O24
• Purity: ~80% (HPLC)
• Suitability: suitable for fluorescence
• Fluorescence: λex 440 nm; λem 523 nm in 5 mM Tris; DNA
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
suitable for detection of DNA
Other Notes
Fluorescent stain for DNA in flow cytometry1,2
Biochem/physiol Actions
Anticancer antibiotic. Inhibits transcription and protein synthesis. Binds to DNA in native chromatin. Substrate of Pgp in MDR phenotypes.

Description (简体中文)

Application
suitable for detection of DNA
Other Notes
Fluorescent stain for DNA in flow cytometry1,2
Biochem/physiol Actions
抗癌抗生素。抑制转录和蛋白质合成。与天然染色质中的 DNA 结合。MDR 表型的 Pgp 底物。