Ibotenic acid monohydrate from Amanita sp.

• Catalog No.: 56720
• CAS Number: 60573-88-8
• M. F.: C5H8N2O5
• M. W.: 176.12742
• Purity: ≥99.0% (TLC)

SYNONYMS

• Title: 鹅膏氨酸 一水合物 来源于鹅膏 属
• IUPAC name: 2-amino-2-(3-oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid hydrate
• IUPAC Traditional name: ibotenic acid hydrate
• Synonyms: α-(3-羟基-5-异噁唑基)甘氨酸; α-氨基-3-羟基-5-异噁唑乙酸; α-Amino-3-hydroxy-5-isoxazoleacetic acid; α-(3-Hydroxy-5-isoxazolyl)glycine; α-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic acid; 鹅膏蕈氨酸

DATABASE IDS

• MDL Number: MFCD00150903
• CAS Number: 60573-88-8
• PubChem SID: 24880352
• Beilstein Number: 1075440

PROPERTIES

• Empirical Formula (Hill Notation): C5H6N2O4 · H2O
• Purity: ≥99.0% (TLC)
• Melting Point: 148-151 °C
• Solubility: 1 M NH4OH: soluble50 mg/mL, clear, colorless to yellow
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• Risk Statements: 25
• RTECS: NY2100000
• Safety Statements: 36/37/39-45
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Review1; Studies on the glutamate receptor2
Biochem/physiol Actions
Ibotenic acid, a 3-isoxazolol amino acid, is an AMPA subtype glutamate receptor agonist involved in signal activation and blockade. Ibotenic acid from mushrooms such as Amanita muscaria and pantherina is an inducer of the “pantherina” central nervous system poisoning syndrome.
Ibotenic acid, a mushroom chemical neurotoxin, is used alone and together with factors such as β-amyloid(25-35) to induce neurotoxic lesions in the brain.

Description (简体中文)

Other Notes
Review1; Studies on the glutamate receptor2
Biochem/physiol Actions
Ibotenic acid, a 3-isoxazolol amino acid, is an AMPA subtype glutamate receptor agonist involved in signal activation and blockade. Ibotenic acid from mushrooms such as Amanita muscaria and pantherina is an inducer of the “pantherina” central nervous system poisoning syndrome.