(+)-Fluprostenol

• Catalog No.: F4176
• M. F.: C23H29F3O6
• M. W.: 458.4679696
• Purity: ≥95%

SYNONYMS

• IUPAC name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoic acid
• IUPAC Traditional name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoic acid
• Synonyms: (+)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2α; (+)-9α,11α,15R-Trihydroxy-16-[3-(trifluoromethyl)phenoxy]-17,18,19,20-tetranorprosta-5Z,13E-dien-1-oic acid

DATABASE IDS

• EC Number: 200-578-6
• MDL Number: MFCD00210955

PROPERTIES

• abs.: ε/222 nm 9,700
• Empirical Formula (Hill Notation): C23H29F3O6
• Purity: ≥95%
• Shipped in: wet ice
• Apperance: ethanol solution
• Flash Point: 14 °C
• Flash Point: 57.2 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H225
• European Hazard Symbols: Flammable (F)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P210
• RID/ADR: UN 1170 3/PG 2
• Risk Statements: 11
• Safety Statements: 7-16
• Storage Temperature: -20°C
• Hazard Class: 3
• UN Number: 1170
• Packing Group: 2
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Metabolically stable analog of PGF2α ; potent FP prostanoid receptor agonist. The optically active enantiomer of fluprostenol. This product is expected to have twice the potency of (+/-)-fluprostenol. It inhibits PGF2α binding to human and rat FP receptors (IC50 values of 3.5 and 7.5 nM respectively). It is a more potent luteolytic agent than PGF2α in rat and also an inhibitor of rat adipose precursor differentiation in primary cultures (IC50 = 3 to 10 ×10-11 M).

Description (简体中文)

Biochem/physiol Actions
Metabolically stable analog of PGF2α ; potent FP prostanoid receptor agonist. The optically active enantiomer of fluprostenol. This product is expected to have twice the potency of (+/-)-fluprostenol. It inhibits PGF2α binding to human and rat FP receptors (IC50 values of 3.5 and 7.5 nM respectively). It is a more potent luteolytic agent than PGF2α in rat and also an inhibitor of rat adipose precursor differentiation in primary cultures (IC50 = 3 to 10 ×10-11 M).