Rhizoxin from Rhizopus sp.

• Catalog No.: R8149
• CAS Number: 90996-54-6
• M. F.: C35H47NO9
• M. W.: 625.74898
• Purity: >95% (HPLC)

SYNONYMS

• IUPAC name: (1S,3S,5R,8S,10S,11S,13R,16R,17R)-10-hydroxy-8-[(2S,3R)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.0^3,^5.0^1^1,^1^3]henicos-14-ene-6,19-dione
• IUPAC Traditional name: (1S,3S,5R,8S,10S,11S,13R,16R,17R)-10-hydroxy-8-[(2S,3R)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.0^3,^5.0^1^1,^1^3]henicos-14-ene-6,19-dione

DATABASE IDS

• MDL Number: MFCD01939948
• CAS Number: 90996-54-6
• PubChem SID: 24899405

PROPERTIES

• Purity: >95% (HPLC)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: VI1800000
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
An antitumor agent, rhizoxin is a 16-member ring lactone having an oxazole ring in its structure. This macrolide inhibits microtubule assembly and also depolymerizes pre-formed microtubles. Rhizoxin binds to β-tubulin in most eucaryotic cells including animals, plants and fungi. It completely prevents formation of an intrachain cross-link in β-tubulin by N,N′-ethylene-bis-(iodo-acetamide). Due to its antimitotic activity it is used as an antitumor agent e.g., in human small cell lung cancer cell lines.

Description (简体中文)

Biochem/physiol Actions
An antitumor agent, rhizoxin is a 16-member ring lactone having an oxazole ring in its structure. This macrolide inhibits microtubule assembly and also depolymerizes pre-formed microtubles. Rhizoxin binds to β-tubulin in most eucaryotic cells including animals, plants and fungi. It completely prevents formation of an intrachain cross-link in β-tubulin by N,N′-ethylene-bis-(iodo-acetamide). Due to its antimitotic activity it is used as an antitumor agent e.g., in human small cell lung cancer cell lines.