Amphotericin B from Streptomyces sp.

• Catalog No.: A6804
• CAS Number: 1397-89-3
• M. F.: C47H73NO17
• M. W.: 924.07902
• Purity: ~80% (HPLC)

SYNONYMS

• Title: 两性霉素 B 来源于链霉菌 属
• IUPAC name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• IUPAC Traditional name: amphotericin B
• Synonyms: Fungizone

DATABASE IDS

• MDL Number: MFCD00877763
• CAS Number: 1397-89-3
• EC Number: 215-742-2
• Beilstein Number: 78342

PROPERTIES

• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3
• GHS Signal Word: Warning
• Empirical Formula (Hill Notation): C47H73NO17
• Purity: ~80% (HPLC)
• Suitability: plant cell culture tested
• Solubility: DMF: 1 M HCl (3:1): soluble, clear to slightly hazy

DETAILS

Description (English)

Application
Recommended for antifungal use in cell culture media at 2.5 mg/L. Stable at 37 °C for 3 days.
Biochem/physiol Actions
Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast.
Amphotericin B Streptomyces sp. Is a polyene antifungal antibiotic that forms membrane channels.

Description (简体中文)

Application
Recommended for antifungal use in cell culture media at 2.5 mg/L. Stable at 37 °C for 3 days.
Biochem/physiol Actions
Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast.
Amphotericin B Streptomyces sp. Is a polyene antifungal antibiotic that forms membrane channels.