Diethyl isocyanomethylphosphonate

• Catalog No.: I0514
• CAS Number: 41003-94-5
• M. F.: C6H12NO3P
• M. W.: 177.138141
• Purity: >97% (GC)

SYNONYMS

• Title: 异腈甲基膦酸二乙酯
• IUPAC name: diethyl (isocyanomethyl)phosphonate
• IUPAC Traditional name: diethyl isocyanomethylphosphonate
• Synonyms: Isocyanomethylphosphonic acid diethyl ester

DATABASE IDS

• CAS Number: 41003-94-5
• Beilstein Number: 4674920
• MDL Number: MFCD00042951

PROPERTIES

• Linear Formula: CNCH2P(O)(OC2H5)2
• Purity: >97% (GC)
• Boiling Point: 84-87 °C/0.1 mmHg(lit.)
• Density: 1.105 g/mL at 25 °C(lit.)
• Flash Point: 113 °C
• Flash Point: 235 °F
• Refractive Index: n20/D 1.433(lit.)
• European Hazard Symbols: Irritant (Xi)
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Precursor for synthesis of phosphonic acid analogs of α-amino acids.
Reactant for:
• Copper-catalyzed cycloaddition reactions1
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase2
• Synthesis of sterol analogs as antifungal agents against plant pathogens3
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions4
• The Passerini reaction5

Description (简体中文)

Application
用于合成 α-氨基酸的膦酸类似物的前体。
Reactant for:
• Copper-catalyzed cycloaddition reactions1
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase2
• Synthesis of sterol analogs as antifungal agents against plant pathogens3
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions4
• The Passerini reaction5