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T-2 Toxin

Catalog No. T4887 Name Sigma Aldrich
CAS Number 21259-20-1 Website http://www.sigmaaldrich.com
M. F. C24H34O9 Telephone 1-800-521-8956
M. W. 466.52136 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 129684

SYNONYMS

Title
T-2 毒素
IUPAC name
(1'S,2S,2'R,4'S,7'R,9'R,10'R,11'S)-11'-(acetyloxy)-2'-[(acetyloxy)methyl]-10'-hydroxy-1',5'-dimethyl-8'-oxaspiro[oxirane-2,12'-tricyclo[7.2.1.02,7]dodecan]-5'-en-4'-yl 3-methylbutanoate
IUPAC Traditional name
T-2 mycotoxin
Synonyms
4β,15-二乙酰氧基-3α-羟基-8α-(3-甲基丁酰氧)-12,13-环氧单端孢霉-9-烯
4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol-4,15-diacetate-8-isovalerate
12,13-环氧单端孢霉-9-烯-3,4,8,15-四醇-4,15-二醋酸酯-8-异戊酸酯

DATABASE IDS

Beilstein Number 3575695
EC Number 244-297-7
MDL Number MFCD00871255
CAS Number 21259-20-1
PubChem SID 24900234

PROPERTIES

Biological Source from Fusarium sp.
Empirical Formula (Hill Notation) C24H34O9
Purity ≥98% (HPLC)
Apperance white powder
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H300-H310-H315-H330
European Hazard Symbols Highly toxic Highly toxic (T+)
MSDS Link Download
GHS Precautionary statements P260-P264-P280-P284-P302 + P350-P310
RID/ADR UN 3462 6.1/PG 1
Risk Statements 26/27/28-38
RTECS YD0100000
Safety Statements 22-28-36/37/39-45
Storage Temperature -20°C
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Class 6.1
UN Number 3462
Packing Group 1
German water hazard class 3

DETAILS

Description (English)
Quality
Chromatographically purified
Biochem/physiol Actions
The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.
Description (简体中文)
Quality
Chromatographically purified
Biochem/physiol Actions
The trichothecenes, such as T2 Toxin, are mycotoxins produced by fungi of the genus Fusarium. They are commonly present in foods and feed of cereal origin. T-2 toxin induces DNA damage and cell death on prolonged administration. These effects can be partially blocked by antioxidants, such as glutathione, coenzyme Q10, or α-tocopherol. Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.

REFERENCES