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Dp44mT

Catalog No. SML0186 Name Sigma Aldrich
CAS Number 152095-12-0 Website http://www.sigmaaldrich.com
M. F. C14H15N5S Telephone 1-800-521-8956
M. W. 285.3674 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 153299

SYNONYMS

IUPAC name
1-{[bis(pyridin-2-yl)methylidene]amino}-3,3-dimethylthiourea
IUPAC Traditional name
1-{[bis(pyridin-2-yl)methylidene]amino}-3,3-dimethylthiourea
Synonyms
Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone
2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide

DATABASE IDS

CAS Number 152095-12-0
MDL Number MFCD20527329

PROPERTIES

Empirical Formula (Hill Notation) C14H15N5S
Purity ≥98% (HPLC)
Apperance yellow to orange powder
Solubility DMSO: ≥5 mg/mL
MSDS Link Download
Storage Temperature 2-8°C

DETAILS

Description (简体中文)
Caution
Material appears to be unstable in solution; make solutions immediately before use.
Biochem/physiol Actions
Dp44mT is an iron chelator that works as a selective anticancer agent. As other iron chelators it can serve as a therapeutic adjunct to doxorubicin treatment. Additionally Dm44mT possess DNA-damaging activity. It appears that that activity is mediated by top2a inhibition.

REFERENCES