S 17092

• Catalog No.: SML0181
• CAS Number: 176797-26-5
• M. F.: C22H28N2O2S
• M. W.: 384.53492
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S,3aS,7aS)-1-[(1R,2R)-2-phenylcyclopropanecarbonyl]-2-(1,3-thiazolidine-3-carbonyl)-octahydro-1H-indole
• IUPAC Traditional name: (2S,3aS,7aS)-1-[(1R,2R)-2-phenylcyclopropanecarbonyl]-2-(1,3-thiazolidine-3-carbonyl)-octahydroindole
• Synonyms: (2S,3aS,7aS)-1-(((R,R)-2-Phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1H-indole; [(2S,3aS,7aS)-Octahydro-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-1H-indol-2-yl]-3-thiazolidinyl--methanone

DATABASE IDS

• CAS Number: 176797-26-5
• MDL Number: MFCD00948255

PROPERTIES

• Empirical Formula (Hill Notation): C22H28N2O2S
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Optical Rotation: [α]/D -140 to -170° in dichloromethane
• Solubility: DMSO: ≥10 mg/mL
• Storage Temperature: 2-8°C

DETAILS

Description (简体中文)

Biochem/physiol Actions
S-17092 is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki=1.5 nM. Nootropic. S-17092 inhibition of POP prevents breakdown and thus increases the activity of a number of neuropeptides, which is likely the basis for its nootropic activity. S 17092 has been shown to improve cognition. It improved cognitive task performance in chronic low dose MPTP-treated monkeys. S-17092 was recently used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin ?4 (T?4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.