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Tolcapone

Catalog No. SML0150 Name Sigma Aldrich
CAS Number 134308-13-7 Website http://www.sigmaaldrich.com
M. F. C14H11NO5 Telephone 1-800-521-8956
M. W. 273.24084 Fax
Purity ≥98% (HPLC) Email
Storage desiccated Chembase ID: 208

SYNONYMS

IUPAC name
5-(4-methylbenzoyl)-3-nitrobenzene-1,2-diol
IUPAC Traditional name
tolcapone (product)
Synonyms
3,4-Dihydroxy-4′-methyl-5-nitrobenzophenone
Ro 40-7592

DATABASE IDS

MDL Number MFCD00866569
CAS Number 134308-13-7

PROPERTIES

Empirical Formula (Hill Notation) C14H11NO5
Purity ≥98% (HPLC)
Apperance yellow powder
Solubility DMSO: ≥15 mg/mL
MSDS Link Download
Storage Condition desiccated
Storage Temperature 2-8°C

DETAILS

Description (简体中文)
Biochem/physiol Actions
Tolcapone is an orally active catechol-O-methyltransferase (COMT) inhibitor. It inhibits both central and peripheral COMT. Tolcapone crosses the blood-brain barrier, and has been used for L-DOPA adjunct therapy in the treatment of Parkinson′s Disease.

REFERENCES