EM20-25

• Catalog No.: SML0183
• CAS Number: 141266-44-6
• M. F.: C15H9ClN4O6
• M. W.: 376.70816
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5-{7-chloro-2,4-dioxo-1H,2H,3H,4H,5H-chromeno[2,3-d]pyrimidin-5-yl}-1,3-diazinane-2,4,6-trione
• IUPAC Traditional name: 5-{7-chloro-2,4-dioxo-1H,3H,5H-chromeno[2,3-d]pyrimidin-5-yl}-1,3-diazinane-2,4,6-trione
• Synonyms: 5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione

DATABASE IDS

• MDL Number: MFCD00624842
• CAS Number: 141266-44-6

PROPERTIES

• Empirical Formula (Hill Notation): C15H9ClN4O6
• Purity: ≥98% (HPLC)
• Apperance: light yellow to yellow powder
• Solubility: DMSO: ≥5 mg/mL at ~60 °C
• Storage Temperature: 2-8°C

DETAILS

Description (简体中文)

Biochem/physiol Actions
EM20-25 is an analog of HA14-1 that antagonizes the effects of the anti-apoptotic protein BCL-2, and causes opening of the mitochondrial permeability transition pore. Unlike HA14-1, EM20-25 does not effect mitochondrial respiration.