R18 trifluoroacetate

• Catalog No.: SML0108
• CAS Number: 211364-78-2(freebase)
• M. F.: C103H158F3N27O31S3
• M. W.: 2423.7091296
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-1-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2R)-2-[(2S)-3-(1H-imidazol-4-yl)-2-[(2S)-pyrrolidin-2-ylformamido]propanamido]-3-sulfanylpropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-carboxypropanamido]-4-methylpentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-carboxypropanamido]-4-methylpentanamido]-4-carboxybutanamido]propanamido]-3-carbamoylpropanamido]-4-(methylsulfanyl)butanamido]-3-sulfanylpropanamido]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid; trifluoroacetic acid
• IUPAC Traditional name: (2S)-1-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2R)-2-[(2S)-3-(1H-imidazol-4-yl)-2-[(2S)-pyrrolidin-2-ylformamido]propanamido]-3-sulfanylpropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-carboxypropanamido]-4-methylpentanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-4-methylpentanamido]-3-carboxypropanamido]-4-methylpentanamido]-4-carboxybutanamido]propanamido]-3-carbamoylpropanamido]-4-(methylsulfanyl)butanamido]-3-sulfanylpropanamido]-4-methylpentanoyl]pyrrolidine-2-carboxylic acid; trifluoroacetic acid
• Synonyms: L-Prolyl-L-histidyl-L-cysteinyl-L-valyl-L-prolyl-L-arginyl-L-a-aspartyl-L-leucyl-L-seryl-L-tryptophyl-L-leucyl-L-a-aspartyl-L-leucyl-L-a-glutamyl-L-alanyl-L-asparaginyl-L-methionyl-L-cysteinyl-L-leucyl-L-proline trifluoroacetate; PHCVPRDLSWLDLEANMCLP trifluoroacetate; Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro trifluoroacetate

DATABASE IDS

• MDL Number: MFCD20527319
• CAS Number: 211364-78-2(freebase)

PROPERTIES

• Empirical Formula (Hill Notation): C101H157N27O29S3
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: white to off-white powder
• Storage Temperature: -20°C

DETAILS

Description (简体中文)

Biochem/physiol Actions
R18 is a competitive inhibitor of the 14-3-3 scaffolding proteins. It binds to the general binding groove of 14-3-3. R18 blocks 14-3-3 interaction with most or all of its client proteins.