dPPA

• Catalog No.: D7821
• CAS Number: 54662-30-5
• M. F.: C30H36O7
• M. W.: 508.60264
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: [(1R,2S,6R,10S,11R,13S,15R)-1,6-dihydroxy-4,12,12,15-tetramethyl-5-oxo-13-[(2-phenylacetyl)oxy]tetracyclo[8.5.0.0^2,^6.0^1^1,^1^3]pentadeca-3,8-dien-8-yl]methyl acetate
• IUPAC Traditional name: [(1R,2S,6R,10S,11R,13S,15R)-1,6-dihydroxy-4,12,12,15-tetramethyl-5-oxo-13-[(2-phenylacetyl)oxy]tetracyclo[8.5.0.0^2,^6.0^1^1,^1^3]pentadeca-3,8-dien-8-yl]methyl acetate
• Synonyms: 12-Deoxyphorbol 13-phenylacetate 20-acetate; DOPPA

DATABASE IDS

• CAS Number: 54662-30-5

PROPERTIES

• Empirical Formula (Hill Notation): C30H36O7
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥5 mg/mL
• Storage Temperature: -20°C

DETAILS

Description (简体中文)

Biochem/physiol Actions
Selective activator of PKC beta
dPPA is a phorbol ester that selectively activates the beta isotype of PKC. It is approximately 100-fold more potent for PKC-beta than the alpha, gamma or delta isotypes. PKC family members each have specific functions, but PKC-beta and delta appear to share similar expression profiles, and both are involved in regulating apoptosis and B cell activation, thus dPPA is a useful tool in determining PKCbeta specific signaling events.