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Crizotinib

Catalog No. PZ0191 Name Sigma Aldrich
CAS Number 877399-52-5 Website http://www.sigmaaldrich.com
M. F. C21H22Cl2FN5O Telephone 1-800-521-8956
M. W. 450.3366832 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 6303

SYNONYMS

IUPAC name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
IUPAC Traditional name
crizotinib
Synonyms
PF02341066
(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
PF 2341066
PF-02341066
Xalkori

DATABASE IDS

CAS Number 877399-52-5
MDL Number MFCD12407409

PROPERTIES

Empirical Formula (Hill Notation) C21H22Cl2FN5O
Purity ≥98% (HPLC)
Apperance white to tan powder
MSDS Link Download
Storage Temperature room temp

DETAILS

Description (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Crizotinib (PF-02341066) is an ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor) and anaplastic lymphoma kinase (ALK). It is a highly specific inhibitor of c-Met and ALK among > 120 different RTKs surveyed. Crizotinib was recently approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.

REFERENCES