M30 dihydrochloride

• Catalog No.: SML0128
• CAS Number: 64821-19-8
• M. F.: C14H16Cl2N2O
• M. W.: 299.19564
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 5-{[methyl(prop-2-yn-1-yl)amino]methyl}quinolin-8-ol dihydrochloride
• IUPAC Traditional name: 5-{[methyl(prop-2-yn-1-yl)amino]methyl}quinolin-8-ol dihydrochloride
• Synonyms: VAR10300 dihydrochloride; M-30 dihydrochloride; 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride

DATABASE IDS

• MDL Number: MFCD20488063
• CAS Number: 64821-19-8

PROPERTIES

• Empirical Formula (Hill Notation): C14H14N2O · 2HCl
• Purity: ≥98% (HPLC)
• Apperance: green-yellow powder
• Solubility: DMSO, heptane and xylene: ≥21 mg/mL
• Storage Condition: desiccated
• Storage Temperature: 2-8°C

DETAILS

Description (简体中文)

Biochem/physiol Actions
M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.