TFLLR-NH2 trifluoroacetate salt

• Catalog No.: T7830
• M. F.: C33H54F3N9O8
• M. W.: 761.8325696
• Purity: >98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-phenylpropanamido]-N-[(1S)-1-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-3-methylbutyl]-4-methylpentanamide; trifluoroacetic acid
• IUPAC Traditional name: (2S)-2-[(2S)-2-[(2S,3R)-2-amino-3-hydroxybutanamido]-3-phenylpropanamido]-N-[(1S)-1-{[(1S)-4-carbamimidamido-1-carbamoylbutyl]carbamoyl}-3-methylbutyl]-4-methylpentanamide; trifluoroacetic acid
• Synonyms: L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt; Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

DATABASE IDS

• MDL Number: MFCD05663482

PROPERTIES

• Empirical Formula (Hill Notation): C31H53N9O6 · xC2HF3O2
• Purity: >98% (HPLC)
• Apperance: white to tan lyophilized powder
• Solubility: H2O: >2 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Amino Acid Sequence
Thr-Phe-Leu-Leu-Arg-NH2
Biochem/physiol Actions
TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

Description (简体中文)

Amino Acid Sequence
Thr-Phe-Leu-Leu-Arg-NH2
Biochem/physiol Actions
TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.