Terameprocol

• Catalog No.: T3455
• CAS Number: 24150-24-1
• M. F.: C22H30O4
• M. W.: 358.4712
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[(2R,3S)-3-[(3,4-dimethoxyphenyl)methyl]-2-methylbutyl]-1,2-dimethoxybenzene
• IUPAC Traditional name: 4-[(2R,3S)-3-[(3,4-dimethoxyphenyl)methyl]-2-methylbutyl]-1,2-dimethoxybenzene
• Synonyms: tetramethyl NDGA; tetra-O-methyl-NDGA; Tetra-O-methyl nordihydroguaiaretic acid; 2,3-Dimethyl-1,4-bis-(3,4-dimethoxyphenyl)butane; EM-1421; M4N; TMNDGA; rel-4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene; tetramethyl Nordihydroguaiaretic Acid

DATABASE IDS

• MDL Number: MFCD11113155
• CAS Number: 24150-24-1

PROPERTIES

• Empirical Formula (Hill Notation): C22H30O4
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H410
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P501
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 50/53
• Safety Statements: 60-61
• Storage Temperature: -20°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.

Description (简体中文)

Biochem/physiol Actions
Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.