Garcinol

• Catalog No.: G5173
• CAS Number: 78824-30-3
• M. F.: C38H50O6
• M. W.: 602.8
• Purity: ≥95%

SYNONYMS

• IUPAC name: (1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-[(2S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl]-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione
• IUPAC Traditional name: garcinol
• Synonyms: Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione

DATABASE IDS

• CAS Number: 78824-30-3
• MDL Number: MFCD03700761

PROPERTIES

• Empirical Formula (Hill Notation): C38H50O6
• Purity: ≥95%
• Apperance: powder, yellow
• Solubility: : >5 mg/mL
• Storage Temperature: -20°C

DETAILS

Description (简体中文)

Biochem/physiol Actions
Garcinol is a HAT (histone acetyltransferase) inhibitor. Garcinol is anti-inflammatory and anti-carcinogenic. Histone acetyltransferases provide opposing enzymatic mechanisms for chromatin remodeling and epigenetic control of gene expression. HATs are involved in regulation of transformation, transcription, differentiation, apoptosis, embryonic development and oncogenesis. IC50 p300 = 7 mM; IC50 PCAF = 5 mM (similar to anacardic acid). Garcinol is highly toxic compared to LTK-14, and does not discriminate between p300 and PCAF.