Methotrexate

• Catalog No.: M4010
• CAS Number: 133073-73-1
• M. F.: C20H24N8O6
• M. W.: 472.45456

SYNONYMS

• Title: 甲氨蝶呤
• IUPAC name: (2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
• IUPAC Traditional name: hydrate methotrexate
• Synonyms: 甲氨蝶呤 水合物; 氨甲叶酸 水合物; MTX 水合物; 4-Amino-10-methylfolic acid hydrate; L-4-Amino-N10-methylpteroylglutamic acid hydrate; L-Amethopterin hydrate; Antifolan hydrate; MTX hydrate; Methotrexate hydrate; Methylaminopterin hydrate; 对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物; L-氨甲喋呤 水合物; 氟安定 水合物; 氨甲喋呤 水合物

DATABASE IDS

• MDL Number: MFCD00150847
• CAS Number: 133073-73-1
• EC Number: 200-413-8

PROPERTIES

• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• RID/ADR: UN 1544 6.1/PG 3
• Risk Statements: 61-25-36/38
• RTECS: MA1225000
• Safety Statements: 53-26-36/37-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 1544
• Packing Group: 3
• German water hazard class: 3
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H315-H319-H360
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P201-P301 + P310-P305 + P351 + P338-P308 + P313
• Empirical Formula (Hill Notation): C20H22N8O5 · xH2O
• Suitability: meets EP, USP testing specifications

DETAILS

Description (English)

Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Description (简体中文)

Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.