Sp 5,6-DCl-cBIMPS

• Catalog No.: S6069
• CAS Number: 120912-54-1
• M. F.: C12H10Cl2N2NaO5PS
• M. W.: 419.152731
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: sodium [(2S,4aR,6R,7R,7aS)-6-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-yl]sulfanide
• IUPAC Traditional name: sodium [(2S,4aR,6R,7R,7aS)-6-(5,6-dichloro-1,3-benzodiazol-1-yl)-7-hydroxy-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-yl]sulfanide
• Synonyms: 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3′,5′-cyclic monophosphorothioate, Sp- isomer sodium salt

DATABASE IDS

• MDL Number: MFCD06795834
• CAS Number: 120912-54-1
• PubChem SID: 24724615

PROPERTIES

• Empirical Formula (Hill Notation): C12H10Cl2N2O5PSNa
• Purity: ≥98% (HPLC)
• Shipped in: dry ice
• Apperance: white solid
• Solubility: H2O: soluble1 mM
• Solubility: DMSO: freely soluble
• Solubility: ethanol: freely soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: -70°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.

Description (简体中文)

Biochem/physiol Actions
Selective cAMP-dependent protein kinase (PKA) activator. Especially suitable for intact cells showing preference for site B of type II isozyme. Completely stable against mammalian cPDE types I & III and only extremely slowly hydrolized by cPDE type II. Surpasses the widely used but problematic dibutyryl cAMP or 8-CPT-cAMP in terms of metabolic stability, membrane permeability and potency.