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SU 9516

Catalog No. S1693 Name Sigma Aldrich
CAS Number 377090-84-1 Website http://www.sigmaaldrich.com
M. F. C13H11N3O2 Telephone 1-800-521-8956
M. W. 241.24534 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 153177

SYNONYMS

IUPAC name
3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3-dihydro-1H-indol-2-one
IUPAC Traditional name
3-(3H-imidazol-4-ylmethylidene)-5-methoxy-1H-indol-2-one

DATABASE IDS

CAS Number 377090-84-1
MDL Number MFCD05865243
PubChem SID 24278633

PROPERTIES

Solubility DMSO: ~17 mg/mL
Solubility H2O: insoluble
Apperance brown crystalline
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class 3
Empirical Formula (Hill Notation) C13H11N3O2
Purity ≥98% (HPLC)
Gene Information human ... CDK2(1017), PDGFRB(5159), SRC(6714)

DETAILS

Description (English)
Application
Identified through a high-throughput screening with Cdk2. IC50=22 nM.
Biochem/physiol Actions
3-substituted indoline cyclin-dependent kinase-2 (Cdk2) inhibitor. Induces apoptosis in colon carcinoma cells.
Description (简体中文)
Application
Identified through a high-throughput screening with Cdk2. IC50=22 nM.
Biochem/physiol Actions
3-substituted indoline cyclin-dependent kinase-2 (Cdk2) inhibitor. Induces apoptosis in colon carcinoma cells.

REFERENCES