MAZ51

• Catalog No.: M1695
• CAS Number: 163655-37-6
• M. F.: C21H18N2O
• M. W.: 314.38042
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-{[4-(dimethylamino)naphthalen-1-yl]methylidene}-2,3-dihydro-1H-indol-2-one
• IUPAC Traditional name: 3-{[4-(dimethylamino)naphthalen-1-yl]methylidene}-1H-indol-2-one
• Synonyms: 3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one

DATABASE IDS

• PubChem SID: 24724533
• MDL Number: MFCD04036983
• CAS Number: 163655-37-6

PROPERTIES

• Empirical Formula (Hill Notation): C21H18N2O
• Purity: ≥98% (HPLC)
• Apperance: orange solid
• Solubility: DMSO: soluble11 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H315-H318-H335-H411
• European Hazard Symbols: Harmful (Xn)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P273-P280-P305 + P351 + P338
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 22-37/38-41-51/53
• Safety Statements: 26-39-61
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).

Description (简体中文)

Biochem/physiol Actions
Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).