JP-1302 trihydrochloride hydrate

• Catalog No.: J4899
• M. F.: C24H29Cl3N4O
• M. W.: 495.87226
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• Title: JP-1302 三盐酸盐 水合物
• IUPAC name: N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine hydrate trihydrochloride
• IUPAC Traditional name: N-[4-(4-methylpiperazin-1-yl)phenyl]acridin-9-amine hydrate trihydrochloride
• Synonyms: Acridin-9-yl-[4-(4-methylpiperazin-1-yl)-phenyl]amine 三盐酸盐 水合物; Acridin-9-yl-[4-(4-methylpiperazin-1-yl)-phenyl]amine trihydrochloride hydrate

DATABASE IDS

• MDL Number: MFCD11045293

PROPERTIES

• Empirical Formula (Hill Notation): C24H27N4Cl3
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: H2O: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H413
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
selective a2C-adrenoceptor antagonist displayed antagonism potencies KB of 1,500, 2,200 and 16 nM at the human a2A-, a2B-, and a2C-adrenoceptor subtypes, respectively; Ki = 28 nM; produced antidepressant and antipsychotic-like effects, i.e. it effectively reduced immobility in the forced specific antagonism of the a2C-adrenoceptor may have therapeutic potential as a novel mechanism for the treatment of neuropsychiatric disorders.

Description (简体中文)

Biochem/physiol Actions
selective a2C-adrenoceptor antagonist displayed antagonism potencies KB of 1,500, 2,200 and 16 nM at the human a2A-, a2B-, and a2C-adrenoceptor subtypes, respectively; Ki = 28 nM; produced antidepressant and antipsychotic-like effects, i.e. it effectively reduced immobility in the forced specific antagonism of the a2C-adrenoceptor may have therapeutic potential as a novel mechanism for the treatment of neuropsychiatric disorders.