KRIBB3

• Catalog No.: K4514
• CAS Number: 129414-88-6
• M. F.: C19H19NO4
• M. W.: 325.35846
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenol
• IUPAC Traditional name: 4-ethyl-5-methoxy-2-[4-(4-methoxyphenyl)-1,2-oxazol-5-yl]phenol
• Synonyms: 5-(5-Ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)isoxazole

DATABASE IDS

• CAS Number: 129414-88-6
• MDL Number: MFCD00710140
• PubChem SID: 24896001

PROPERTIES

• Empirical Formula (Hill Notation): C19H19NO4
• Purity: ≥98% (HPLC)
• Apperance: white to off-white solid
• Solubility: DMSO: soluble15 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H413
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 22
• Storage Condition: protect from light
• Storage Condition: under inert gas
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
KRIBB3 is an inhibitior of PKC-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. It has antimigratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration. The IC50 is 50 nM, suggesting that KRIBB3 has a high specific affinity for the target protein, Hsp27.

Description (简体中文)

Biochem/physiol Actions
KRIBB3 is an inhibitior of PKC-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. It has antimigratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 blocked phorbol 12-myristate 13-acetate-induced phosphorylation of Hsp27 and tumor cell migration. The IC50 is 50 nM, suggesting that KRIBB3 has a high specific affinity for the target protein, Hsp27.