Fascaplysin chloride hydrate

• Catalog No.: F7804
• CAS Number: 114719-57-2(anhydrous)
• M. F.: C18H13ClN2O2
• M. W.: 324.76102
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 20-oxo-3,13λ^5-diazapentacyclo[11.7.0.0^2,^1^0.0^4,^9.0^1^4,^1^9]icosa-1(13),2(10),4(9),5,7,11,14(19),15,17-nonaen-13-ylium hydrate chloride
• IUPAC Traditional name: 20-oxo-3,13λ^5-diazapentacyclo[11.7.0.0^2,^1^0.0^4,^9.0^1^4,^1^9]icosa-1(13),2(10),4(9),5,7,11,14(19),15,17-nonaen-13-ylium hydrate chloride
• Synonyms: Fascaplysine 水合物; Fascaplysine hydrate; 12,13-Dihydro-13-oxopyrido[1,2-a:3,4-b′]diindol-5-ium chloride

DATABASE IDS

• MDL Number: MFCD09752600
• CAS Number: 114719-57-2(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C18H11ClN2O · xH2O
• Purity: ≥98% (HPLC)
• Apperance: brick red solid
• Solubility: H2O: <2 mg/mL
• Solubility: DMSO: ~20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Originally isolated from the marine sponge Thorectandra sp., fascaplysin chloride is a selective, potent inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM). It is significantly less selective for Cdk6/D1 (IC50 = 3.4 μM) and not selective for the other Cdks and tyrosine kinases.

Description (简体中文)

Biochem/physiol Actions
Originally isolated from the marine sponge Thorectandra sp., fascaplysin chloride is a selective, potent inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50 = 0.35 μM). It is significantly less selective for Cdk6/D1 (IC50 = 3.4 μM) and not selective for the other Cdks and tyrosine kinases.