Imiquimod

• Catalog No.: I5159
• CAS Number: 99011-02-6
• M. F.: C14H16N4
• M. W.: 240.30364
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
• IUPAC Traditional name: imiquimod
• Synonyms: 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine

DATABASE IDS

• MDL Number: MFCD00866946
• PubChem SID: 24724516
• CAS Number: 99011-02-6

PROPERTIES

• Empirical Formula (Hill Notation): C14H16N4
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: H2O: <2 mg/mL
• Solubility: DMSO: soluble4 mg/mL (warming to 60 °C for 15 minutes)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P261-P264-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-36/37/38
• Safety Statements: 26-45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.

Description (简体中文)

Biochem/physiol Actions
Imiquimod is a caspase 3 activator, which directly induces procaspase 3 cleavage to active caspase 3. Imiquimod induces apoptosis in vivo in basal cell carcinoma. Its anti-tumor activity is related to the induction of apoptosis. Imiquimod has anti-angiogenic, anti-inflammatory, anti-viral activities. Imiquimod also acts as an immune response modulator inducing the secretion of various cytokines and chemokines.