BN82002 hydrochloride

• Catalog No.: B1061
• CAS Number: 396073-89-5
• M. F.: C19H26ClN3O4
• M. W.: 395.88044
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: 4-(dimethylamino)-2-methoxy-6-({methyl[2-(4-nitrophenyl)ethyl]amino}methyl)phenol hydrochloride
• IUPAC Traditional name: 4-(dimethylamino)-2-methoxy-6-({methyl[2-(4-nitrophenyl)ethyl]amino}methyl)phenol hydrochloride
• Synonyms: 4-Dimethylamino-2-methoxy-6-((methyl-[2-(4-nitrophenyl)ethyl]amino)methyl)phenol

DATABASE IDS

• PubChem SID: 24724410
• CAS Number: 396073-89-5
• MDL Number: MFCD08276984

PROPERTIES

• Empirical Formula (Hill Notation): C19H25N3O4 · xHCl
• Purity: ≥97% (HPLC)
• Apperance: tan solid
• Solubility: DMSO: soluble10 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Caution
Hygroscopic.
Biochem/physiol Actions
BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC50 in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC50 in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).

Description (简体中文)

Caution
Hygroscopic.
Biochem/physiol Actions
BN82002 is a potent, selective, and irreversible CDC25 phosphatase family inhibitor. BN82002 displays ~20-fold greater selectivity over CD45 tyrosine phosphatase (IC50 in μM = 2.4, 3.9, 6.3, 5.4, and 4.6 for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 has been shown to delay cell cycle progression in vitro (IC50 in the range of 7.2 - 32.6 μM). BN82002 reduces tumor growth in athymic mice xenografted with the human pancreatic cell MIA PaCa-2 (15 mg/kg, i.p. route).