Rifampicin

• Catalog No.: 83907
• CAS Number: 13292-46-1
• M. F.: C43H58N4O12
• M. W.: 822.94022
• Purity: ≥97.0% (HPLC)

SYNONYMS

• Title: 利福平
• IUPAC name: (7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^4,^7.0^5,^2^8]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
• IUPAC Traditional name: (7S,11S,12R,13S,14R,15R,16R,17S,18S)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[N-(4-methylpiperazin-1-yl)carboximidoyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1^4,^7.0^5,^2^8]triaconta-1,3,5(28),9,19,21,25(29),26-octaen-13-yl acetate
• Synonyms: 利米定; 甲哌利福霉素; Rifamycin AMP; 3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampin

DATABASE IDS

• EC Number: 236-312-0
• CAS Number: 13292-46-1
• Beilstein Number: 5723476
• PubChem SID: 24888155
• MDL Number: MFCD00151389

PROPERTIES

• Empirical Formula (Hill Notation): C43H58N4O12
• Purity: ≥97.0% (HPLC)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• RTECS: VJ7000000
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.
Application
Rifampicin is used as a selective cytochrome P4503A4 inducer. Studies have shown that rifampicin inhibits African Swine Fever Virus replication in tissue culture 1 and inhibits the induction of tyrosine aminotransferase by cortisol in rat hepatoma cells grown in culture 2.

Description (简体中文)

Biochem/physiol Actions
Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.
Application
Rifampicin is used as a selective cytochrome P4503A4 inducer. Studies have shown that rifampicin inhibits African Swine Fever Virus replication in tissue culture 1 and inhibits the induction of tyrosine aminotransferase by cortisol in rat hepatoma cells grown in culture 2.