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Metharbital

Catalog No. DB00463 Name DrugBank
CAS Number 50-11-3 Website http://www.ualberta.ca/
M. F. C9H14N2O3 Telephone (780) 492-3111
M. W. 198.21906 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 346

SYNONYMS

IUPAC name
5,5-diethyl-1-methyl-1,3-diazinane-2,4,6-trione
IUPAC Traditional name
metharbital
Brand Name
Endiemal
Metabarbital
Methabarbitone
Methylbarbital
Endiemalum
Gemonal
Gemonil
Gemonit
Metarbital [INN-Spanish]
Metarbitale [Dcit]
Methabarbital
Metharbital [INN:Jan]
Metharbitalum [INN-Latin]
Metharbitone
Metharbutal
N-Methylbarbital

DATABASE IDS

PubChem CID 4099
PubChem SID 46508167
CAS Number 50-11-3

PROPERTIES

Hydrophobicity(logP) 0.6
Solubility 1980 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Metharbital was patented in 1905 by Emil Fischer working for Merck. It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy. It has similar properties to phenobarbital.

Indication Metharbital is used for the treatment of epilepsy.
Pharmacology Metharbital, a barbiturate, is used for the treatment of short term insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants that induce drowsiness and relieve tension or nervousness. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Toxicity Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
Affected Organisms
Humans and other mammals
External Links
Wikipedia

REFERENCES