O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate

• Catalog No.: 12804
• CAS Number: 94790-37-1
• M. F.: C11H16F6N5OP
• M. W.: 379.2418202
• Purity: ≥98.0% (T)

SYNONYMS

• Title: 苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯
• IUPAC name: [(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylidene]dimethylazanium; hexafluoro-λ^5-phosphanuide
• IUPAC Traditional name: [(1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylidene]dimethylazanium hexafluorophosphate
• Synonyms: N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate; HBTU; N,N,N′,N′-四甲基-O-(1H-苯并三氮唑)六氟磷酸脲

DATABASE IDS

• Beilstein Number: 7328329
• EC Number: 423-020-5
• PubChem SID: 24847817
• CAS Number: 94790-37-1
• MDL Number: MFCD00075445

PROPERTIES

• Empirical Formula (Hill Notation): C11H16F6N5OP
• Purity: ≥98.0% (T)
• Melting Point: 200 °C (dec.)(lit.)
• Solubility: acetonitrile: soluble0.1 g/mL, clear
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Application
最近研究显示这种偶联试剂的晶体和溶液结构是胍的 N-氧化物形式，而不是一种脲化合物；1 用于肽合成的偶联剂；其优点在于：外消旋作用极低、反应条件简单、反应时间极短，以及极高的产率。2,3
包装
1, 5, 25 g in glass bottle

Description (English)

Application
Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound;1 Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields.2,3
Packaging
1, 5, 25 g in glass bottle