1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate

• Catalog No.: 11373
• CAS Number: 148893-10-1
• M. F.: C10H15F6N6OP
• M. W.: 380.2298802
• Purity: ≥98.0% (CHN)

SYNONYMS

• IUPAC name: [(dimethylamino)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})methylidene]dimethylazanium; hexafluoro-λ^5-phosphanuide
• IUPAC Traditional name: [(dimethylamino)({[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})methylidene]dimethylazanium hexafluorophosphate
• Synonyms: HATU; N,N,N′,N′-四甲基-O-(7-氮杂苯并三唑-1-基)六氟磷酸脲; N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide

DATABASE IDS

• CAS Number: 148893-10-1
• PubChem SID: 24847146

PROPERTIES

• Empirical Formula (Hill Notation): C10H15F6N6OP
• Purity: ≥98.0% (CHN)
• Melting Point: 183-185 °C(lit.)
• Melting Point: 183-188 °C (dec.)
• GHS Signal Word: Danger
• GHS Hazard statements: H228-H315-H319-H335
• European Hazard Symbols: Explosive (E)
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P210-P261-P305 + P351 + P338
• Risk Statements: 2-36/37/38
• Safety Statements: 26-35
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound;6 Advantageous coupling reagent for solid-phase peptide synthesis7.
Packaging
1, 5, 25 g in poly bottle
Application
Reagent for: Synthesis of Aurora A kinase inhibitors1 HPLC assay to determine D- and L- acid enantiomers in human plasma2 Amide bond formation reactions3Catalyst for: Selective acylation4 Selecocyclization-oxidation deselenation sequence5

Description (简体中文)

Other Notes
最近的研究表明，该偶联剂的晶体及溶液结构是胍的 N-氧化物形式，而不是脲化合物；6适用于固相肽合成的偶联剂7。
包装
1, 5, 25 g in poly bottle
Application
Reagent for: Synthesis of Aurora A kinase inhibitors1 HPLC assay to determine D- and L- acid enantiomers in human plasma2 Amide bond formation reactions3Catalyst for: Selective acylation4 Selecocyclization-oxidation deselenation sequence5