Triethyl 2-phosphonobutyrate

• Catalog No.: 417467
• CAS Number: 17145-91-4
• M. F.: C10H21O5P
• M. W.: 252.244501
• Purity: 98%

SYNONYMS

• Title: 2-膦酰丁酸三乙酯
• IUPAC name: ethyl 2-(diethoxyphosphoryl)butanoate
• IUPAC Traditional name: ethyl 2-(diethoxyphosphoryl)butanoate
• Synonyms: NSC 22423; α-Diethylphosphonobutanoic acid ethyl ester; Ethyl 2-(diethoxyphosphoryl)butanoate

DATABASE IDS

• MDL Number: MFCD00041347
• PubChem SID: 24866152
• CAS Number: 17145-91-4

PROPERTIES

• Linear Formula: (C2H5O)2P(O)CH(C2H5)CO2C2H5
• Purity: 98%
• Boiling Point: 152-154 °C/14 mmHg(lit.)
• Density: 1.064 g/mL at 25 °C(lit.)
• Flash Point: 113 °C
• Flash Point: 235.4 °F
• Refractive Index: n20/D 1.432(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Packaging
5, 25 mL in glass bottle
Application
Reactant for preparation of:
• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents1
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs2
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents3
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists4
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library5
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis6
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)7
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates8
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)9
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis10

Description (简体中文)

包装
5, 25 mL in glass bottle
Application
Reactant for preparation of:
• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents1
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs2
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents3
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists4
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library5
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis6
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)7
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates8
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)9
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis10