4-Hydroxy-TEMPO

• Catalog No.: 176141
• CAS Number: 2226-96-2
• M. F.: C9H18NO2
• M. W.: 172.24472
• Purity: 97%

SYNONYMS

• Title: 哌啶醇氧化物
• IUPAC name: ol
• IUPAC Traditional name: tyrosine(.)
• Synonyms: Tempol; 4-羟基-2,2,6,6-四甲基哌啶-1-氧自由基; 4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl

DATABASE IDS

• PubChem SID: 24850555
• EC Number: 218-760-9
• Beilstein Number: 1422990
• CAS Number: 2226-96-2
• MDL Number: MFCD00006478

PROPERTIES

• Empirical Formula (Hill Notation): C9H18NO2
• Purity: 97%
• Melting Point: 69-71 °C(lit.)
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• RTECS: TN8991000
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Application
A fluorous-tagged TEMPO derivative was prepared from the derived TEMPO propargylic ether and subsequent "click" reaction with a fluorous azide. This TEMPO derivative proved to be a highly effective catalyst in the oxidation of alcohols with bleach.1
Spin label for studying biological compounds and polymers.
Spin label reagent used in the chatacterization of antagonist and agonist binding sites of NK1 receptor. Also used to measure reactive oxygen generation in heart muscle by electron spin resonance spectroscopy. Cells that overexpress CYP2E1 can be protected from arachidonic acid toxicity damage by TEMPOL.
Packaging
1, 5, 25 g in glass bottle

Description (简体中文)

Application
可由衍生化 TEMPO 丙炔醚和随后与氟叠氮化物发生的"点击"反应制备氟标记的 TEMPO 衍生物。在用漂白剂氧化醇的反应中证明该 TEMPO 衍生物是高效催化剂。1
研究生物学化合物和聚合物的自旋标记物。
自旋标记试剂，用于鉴定 NK1 受体的拮抗剂和激动剂结合位点。也可用于电子自旋共振光谱法测定心肌中活性氧的生成。TEMPOL 可保护过量表达 CYP2E1 的细胞免受花生四烯酸的毒性损伤。
包装
1, 5, 25 g in glass bottle