Cefalotin

• Catalog No.: DB00456
• CAS Number: 153-61-7
• M. F.: C16H16N2O6S2
• M. W.: 396.43804

SYNONYMS

• IUPAC name: (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• IUPAC Traditional name: cefalotin
• Brand Name: Seffin; Cemastin; Averon-1; Coaxin; Keflin
• Synonyms: Cephalothinum; CLS; Cephalothin; Cefalotina [INN-Spanish]; Cefalotine [INN-French]; Cefalotinum [INN-Latin]; Cephalothin Sodium; Cephalotin; Cefalothin

DATABASE IDS

• PubChem SID: 46509079
• PubChem CID: 6024
• CAS Number: 153-61-7

PROPERTIES

• Hydrophobicity(logP): -0.2
• Solubility: 158 mg/L

DETAILS

Description (English)

• Drug Groups: approved
• Description: A cephalosporin antibiotic. [PubChem]
• Indication: Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
• Pharmacology: Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.
• Toxicity: Rat intravenous LD₅₀ is 4000 mg/kg.
• Affected Organisms: Enteric bacteria and other eubacteria
• Biotransformation: Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
• Half Life: 30 minutes
• Protein Binding: 65-80%
• External Links: Wikipedia