1,8-Diazabicyclo[5.4.0]undec-7-ene

• Catalog No.: 139009
• CAS Number: 6674-22-2
• M. F.: C9H16N2
• M. W.: 152.23674
• Purity: 98%

SYNONYMS

• Title: 1,8-二氮杂双环[5.4.0]十一碳-7-烯
• IUPAC name: 2H,3H,4H,6H,7H,8H,9H,10H-pyrimido[1,2-a]azepine
• IUPAC Traditional name: 1,8-diazabicycloundec-7-ene
• Synonyms: 2,3,4,6,7,8,9,10-八氢嘧啶并[1,2-a]氮杂卓; DBU; 2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-a]azepine

DATABASE IDS

• CAS Number: 6674-22-2
• EC Number: 229-713-7
• Beilstein Number: 508906
• MDL Number: MFCD00006930
• PubChem SID: 24848373

PROPERTIES

• Empirical Formula (Hill Notation): C9H16N2
• Purity: 98%
• Boiling Point: 80-83 °C/0.6 mmHg(lit.)
• Density: 1.018 g/mL at 25 °C(lit.)
• Flash Point: 116 °C
• Flash Point: 240.8 °F
• Refractive Index: n20/D 1.522-1.524(lit.)
• Vapor Pressure: 5.3 mmHg ( 37.7 °C)
• GHS Signal Word: Danger
• GHS Hazard statements: H290-H301-H314-H412
• European Hazard Symbols: Corrosive (C)
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P273-P280-P301 + P310-P305 + P351 + P338-P310
• RID/ADR: UN 3267 8/PG 2
• Risk Statements: 22-34-52/53
• Safety Statements: 26-36/37/39-45
• Hazard Class: 8
• UN Number: 3267
• Packing Group: 2
• German water hazard class: 2

DETAILS

Description (English)

Application
Halogenated Diels-Alder adducts were dehydrohalogenated with this base, and the resulting activated 2,4-dienones were subjected to regio- and stereo-directed Michael additions, using Yamamoto′s reagent (CH3Cu · BF3).2
Used in a new synthesis of the ABCD ring system of Camptothecin.
Features and Benefits
Strong hindered amine base.
Packaging
25, 100, 500 g in glass bottle
Citation
An application review.1

Description (简体中文)

Application
卤化的 Diels-Alder 加合物使用该碱脱卤化氢，由此得到的活性 2,4-二烯酮使用 Yamamoto 试剂 (CH3Cu · BF3) 进行区域定向和立体定向 Michael 加成反应。2
用于新法合成喜树碱的 ABCD 环系统。
Features and Benefits
强位阻胺碱。
包装
25, 100, 500 g in glass bottle
Citation
应用综述。1