Lithium diisopropylamide solution

• Catalog No.: 361798
• CAS Number: 4111-54-0
• M. F.: C6H14LiN
• M. W.: 107.12306

SYNONYMS

• Title: 二异丙基氨基锂 溶液
• IUPAC name: lithiobis(propan-2-yl)amine
• IUPAC Traditional name: diisopropyl(lithio)amine
• Synonyms: LDA

DATABASE IDS

• CAS Number: 4111-54-0
• Beilstein Number: 3655042
• PubChem SID: 24862259
• MDL Number: MFCD00064449

PROPERTIES

• Concentration: 2.0 M in THF/heptane/ethylbenzene
• Impurities: 3 wt. % diisopropylamine
• Linear Formula: [(CH3)2CH]2NLi
• Density: 0.812 g/mL at 25 °C
• Flash Point: 2 °C
• Flash Point: 35.6 °F
• GHS Signal Word: Danger
• GHS Hazard statements: H225-H250-H261-H304-H314-H335-H336-H361-H410
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Corrosive (C)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P210-P222-P231 + P232-P261-P273-P422
• RID/ADR: UN 3399 4.3/PG 2
• Risk Statements: 63-11-14/15-17-19-34-37-50/53-62-65-67
• Safety Statements: 26-36/37/39-43-45-61-62
• Storage Temperature: 2-8°C
• Supplemental Hazard Statements: May form explosive peroxides.
• Hazard Class: 4.3
• UN Number: 3399
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Application
Titanium-ate enolates prepared from ketones by Ti(OiPr)4 and LDA underwent efficient radical trifluoromethylation providing trifluoromethyl ketones in good yield.1 Used in directed ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs.2
Packaging
4×25, 100, 800 mL in Sure/Seal™

Description (简体中文)

Application
由酮与 Ti(OiPr)4 和 LDA 作用制备的烯醇钛，发生有效自由基三氟甲基化反应，从而以高产率提供三氟甲基酮。1用于芳基磺酰噁唑烷酮的直接邻锂化反应以制备 N-取代糖精类似物。2
包装
4×25, 100, 800 mL in Sure/Seal™