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Framycetin

Catalog No. DB00452 Name DrugBank
CAS Number 119-04-0 Website http://www.ualberta.ca/
M. F. C23H46N6O13 Telephone (780) 492-3111
M. W. 614.64374 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 335

SYNONYMS

IUPAC name
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol
IUPAC Traditional name
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol
Brand Name
Actiline
Soframycine
Neomycin A
Soframycin Ophthalmic
Soframycin
Actilin
Antibiotique
Enterfram
Fradiomycin B
Framygen
Nebramycin X
Negamicin
Dekamycin V
Synonyms
Framycetinum [INN-Latin]
Neomycin B
Streptothricin B

DATABASE IDS

PubChem SID 46508892
PubChem CID 8378
CAS Number 119-04-0

PROPERTIES

Hydrophobicity(logP) -7.8

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Indication For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
Pharmacology Framycetin is used for the treatment of bacterial eye infections such as conjunctivitis. Framycetin is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Framycetin works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Framycetin is useful primarily in infections involving aerobic bacteria bacteria.
Affected Organisms
Enteric bacteria and other eubacteria
External Links
Wikipedia

REFERENCES