Hydrogen fluoride pyridine

• Catalog No.: 184225
• CAS Number: 62778-11-4
• M. F.: C5H6FN
• M. W.: 99.1062432

SYNONYMS

• Title: 吡啶氢氟酸盐
• IUPAC name: pyridine hydrofluoride
• IUPAC Traditional name: pyridine hydrofluoride
• Synonyms: 氟化氢吡啶; Pyridinium polybifluoride; HF-Pyridine; PPHF; Pyridinium poly(hydrogen fluoride); Olah′s reagent; Poly(pyridine fluoride); Pyridine hydrofluoride; HF-吡啶

DATABASE IDS

• MDL Number: MFCD00012436
• Beilstein Number: 4750151
• PubChem SID: 24851101
• CAS Number: 62778-11-4

PROPERTIES

• Compostion: hydrogen fluoride, ~70%
• Compostion: pyridine, ~30%
• Linear Formula: C5H5N · (HF)x
• Density: 1.1 g/mL at 20 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H314-H330
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 1790 8/PG 1
• Risk Statements: 26/27/28-35
• Safety Statements: 26-28-36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 8
• UN Number: 1790
• Packing Group: 1
• German water hazard class: 3

DETAILS

Description (English)

General description
May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.
Packaging
25, 100 g in poly bottle
Application
Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.1,2Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones.3 Employed with Selectfluor™ (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.4
Reactant for preparation of:
• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorinationReagent for:
• Halofluorination reactions
Legal Information
Selectfluor is a registered trademark of Air Products & Chemicals, Inc.
Sure/Pac is a trademark of Sigma-Aldrich Co. LLC

Description (简体中文)

General description
储存期间可能含有或形成少量氟化钙。该物质的存在不会对性能指标产生影响。
包装
25, 100 g in poly bottle
Application
Reactant for preparation of:
• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorinationReagent for:
• Halofluorination reactions
无水 HF 的简易形态，稳定温度高达 50°C。已用于由氨基醇制备 β-氟胺，以及用于炔烃的氟化。1,2 与高价碘(III) 试剂共同用于对位取代酚的 ipso-氟化反应，从而产生环己二烯酮类。3 与 Selectfluor™（目录号 439479）配合用于 2,2-二芳基-1,3-二硫戊环的孪位氟化。4
法律信息
Selectfluor 注册商标 Air Products & Chemicals, Inc.