2,2-Dimethyl-1,3-dioxane-4,6-dione

• Catalog No.: 210145
• CAS Number: 2033-24-1
• M. F.: C6H8O4
• M. W.: 144.12532
• Purity: 98%

SYNONYMS

• Title: 2,2-二甲基-1,3-二噁烷-4,6-二酮
• IUPAC name: 2,2-dimethyl-1,3-dioxane-4,6-dione
• IUPAC Traditional name: meldrum's acid
• Synonyms: 丙二酸亚异丙酯; 米氏酸; Meldrum’s acid; Malonic acid cyclic isopropylidene ester; cycl-Isopropylidene malonate; 丙二酸环亚异丙酯

DATABASE IDS

• EC Number: 217-992-8
• PubChem SID: 24852618
• MDL Number: MFCD00006638
• Beilstein Number: 117310
• CAS Number: 2033-24-1

PROPERTIES

• Empirical Formula (Hill Notation): C6H8O4
• Purity: 98%
• Melting Point: 92-96 °C(lit.)
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Benzyl substituted Meldrum′s acids, available via aldol condensation and reduction with triethylammonium formate,1 were used to form indanones upon hydrolysis, loss of CO2, and Friedel-Crafts cyclization with chlorosulfonic acid.2 Knoevenagel condensations between aldehydes and Meldrum′s acid are accelerated in ionic liquids.3
Used in an efficient synthesis of isofraxidin.
Packaging
10, 25, 100 g in glass bottle

Description (简体中文)

Application
可通过与三乙基碳酸氢铵发生羟醛缩合反应和还原反应而制得苄基取代的米氏酸，1该物质经水解失去 CO2，同时与氯磺酸发生 Friedel-Crafts 环化反应形成茚酮。2可在离子液体中加速醛和米氏酸的 Knoevenagel 缩合反应。3
用于异嗪皮啶的高效合成。
包装
10, 25, 100 g in glass bottle