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Suberohydroxamic acid_Molecular_structure_CAS_38937-66-5)
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Suberohydroxamic acid

Catalog No. 390585 Name Sigma Aldrich
CAS Number 38937-66-5 Website http://www.sigmaaldrich.com
M. F. C8H16N2O4 Telephone 1-800-521-8956
M. W. 204.22364 Fax
Purity 95% Email
Storage Chembase ID: 146062

SYNONYMS

Title
软木肟酸
IUPAC name
N,N'-dihydroxyoctanediamide
IUPAC Traditional name
N,N'-dihydroxyoctanediamide
Synonyms
SBHA
Suberoyl bis-hydroxamic acid
N,N′-Dihydroxyoctanediamide

DATABASE IDS

PubChem SID 24864150
MDL Number MFCD00192455
CAS Number 38937-66-5

PROPERTIES

Linear Formula [-(CH2)3CONHOH]2
Purity 95%
Melting Point 153-155 °C(lit.)
MSDS Link Download
German water hazard class 3

DETAILS

Description (English)
Packaging
1 g in glass bottle
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.
Description (简体中文)
包装
1 g in glass bottle
Biochem/physiol Actions
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. SBHA inhibits the activity of HDAC1 and HDAC3 with IC50 values of 250 and 300 nM, respectively. SBHA inhibits proliferation, and induces apoptosis in several cancer cell lines. SBHA has been shown to activate Notch signaling in medullary thyroid carcinoma (MTC) cells.

REFERENCES