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β-Estradiol

Catalog No. 250155 Name Sigma Aldrich
CAS Number 50-28-2 Website http://www.sigmaaldrich.com
M. F. C18H24O2 Telephone 1-800-521-8956
M. W. 272.38196 Fax
Purity 97% Email
Storage Chembase ID: 663

SYNONYMS

Title
β-雌二醇
IUPAC name
(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
IUPAC Traditional name
estradiol
Synonyms
17β-雌二醇
3,17β-二羟基-1,3,5(10)-雌甾三烯
雌二醇
1,3,5-雌甾三烯-3,17β-二醇
Dihydrofolliculin
1,3,5-Estratriene-3,17β-diol
3,17β-Dihydroxy-1,3,5(10)-estratriene
17β-estradiol

DATABASE IDS

MDL Number MFCD00003693
Beilstein Number 1914275
CAS Number 50-28-2
EC Number 200-023-8

PROPERTIES

Empirical Formula (Hill Notation) C18H24O2
Purity 97%
Melting Point 176-180 °C(lit.)
Optical Rotation [α]20/D +80.4°, c = 1 in dioxane
GHS Pictograms GHS08
GHS Signal Word Danger
GHS Hazard statements H351-H360Fd-H362
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements P201-P263-P281-P308 + P313
Risk Statements 60-63-40-64
RTECS KG2975000
Safety Statements 53-45
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
Description (简体中文)
Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期,通过调控基因转录,并因此调控蛋白合成,从而指导女性表型的发展。它还可诱导促性腺激素的生成,继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

REFERENCES