β-Estradiol

• Catalog No.: 250155
• CAS Number: 50-28-2
• M. F.: C18H24O2
• M. W.: 272.38196
• Purity: 97%

SYNONYMS

• Title: β-雌二醇
• IUPAC name: (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-triene-5,14-diol
• IUPAC Traditional name: estradiol
• Synonyms: 17β-雌二醇; 3,17β-二羟基-1,3,5(10)-雌甾三烯; 雌二醇; 1,3,5-雌甾三烯-3,17β-二醇; Dihydrofolliculin; 1,3,5-Estratriene-3,17β-diol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; 17β-estradiol

DATABASE IDS

• MDL Number: MFCD00003693
• Beilstein Number: 1914275
• CAS Number: 50-28-2
• EC Number: 200-023-8

PROPERTIES

• Empirical Formula (Hill Notation): C18H24O2
• Purity: 97%
• Melting Point: 176-180 °C(lit.)
• Optical Rotation: [α]20/D +80.4°, c = 1 in dioxane
• GHS Signal Word: Danger
• GHS Hazard statements: H351-H360Fd-H362
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P263-P281-P308 + P313
• Risk Statements: 60-63-40-64
• RTECS: KG2975000
• Safety Statements: 53-45
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Description (简体中文)

Biochem/physiol Actions
由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期，通过调控基因转录，并因此调控蛋白合成，从而指导女性表型的发展。它还可诱导促性腺激素的生成，继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。