(S,S′,R,R′)-TangPhos

• Catalog No.: 650889
• CAS Number: 470480-32-1
• M. F.: C16H32P2
• M. W.: 286.372802

SYNONYMS

• IUPAC name: (2R)-1-tert-butyl-2-[(2R)-1-tert-butylphospholan-2-yl]phospholane
• IUPAC Traditional name: (2R)-1-tert-butyl-2-[(2R)-1-tert-butylphospholan-2-yl]phospholane
• Synonyms: (1S,1S′,2R,2R′)-1,1′-Di-tert-butyl-(2,2′)-diphospholane; (1S,1S′,2R,2R′)-1,1′-二叔丁基-(2,2′)-二磷烷

DATABASE IDS

• PubChem SID: 24883788
• CAS Number: 470480-32-1

PROPERTIES

• Empirical Formula (Hill Notation): C16H32P2
• Melting Point: 60-65 °C
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• German water hazard class: 3

DETAILS

Description (English)

Application
Highly efficient in rhodium-catalyzed hydrogenation of α-dehyroamino acids and α-arylenamides,6 β-(acylamino)acrylates,7 itaconic acids, and enol acetates.8 Also gives outstanding enantioselectivities in asymmetric hydroformylation reactions.9
Chiral Quest Phosphine Ligands for Asymmetric HydrogenationCatalytic ligand used in:
• Preparation of α-borono-substituted alkylarenes by asymmetric hydroboration of styrenes catalyzed by copper(I)1
• Enantioselective synthesis of spiroindane di-Me acetic acid via hydrogenation of spiroindane di-Me acetic acid catalyzed by Ru(II)2
• Asymmetric γ-addition of thiols to allenoates3
• Rhodium-catalyzed intermolecular enantioselective hydroacylation of alkynes to give alpha- and beta-substituted unsaturated ketones by kinetic resolution4
• Stereoselective preparation of β-amino nitriles via rhodium-catalyzed asymmetric hydrogenation of amino acrylonitriles5
Packaging
100, 500 mg in glass bottle

Description (简体中文)

Application
在 α-脱氢氨基酸、α-芳基烯酰胺、6β-(酰胺基)丙烯酸酯、7衣康酸以及乙酸烯醇酯的铑催化氢化中具有高效性。8也能在不对称加氢甲酰化反应中提供出色的对映选择性。9
Chiral Quest Phosphine Ligands for Asymmetric HydrogenationCatalytic ligand used in:
• Preparation of α-borono-substituted alkylarenes by asymmetric hydroboration of styrenes catalyzed by copper(I)1
• Enantioselective synthesis of spiroindane di-Me acetic acid via hydrogenation of spiroindane di-Me acetic acid catalyzed by Ru(II)2
• Asymmetric γ-addition of thiols to allenoates3
• Rhodium-catalyzed intermolecular enantioselective hydroacylation of alkynes to give alpha- and beta-substituted unsaturated ketones by kinetic resolution4
• Stereoselective preparation of β-amino nitriles via rhodium-catalyzed asymmetric hydrogenation of amino acrylonitriles5
包装
100, 500 mg in glass bottle