Bis[(S,S,S)-DiazaPhos-SPE]

• Catalog No.: 685259
• CAS Number: 851770-14-4
• M. F.: C78H72N8O8P2
• M. W.: 1311.402602

SYNONYMS

• Title: 2,2′,2″,2′′′-(1,2-亚苯基双[(1S,3S)-四氢-5,8-二氧代-1H-[1,2,4]二氮杂磷杂环戊基[1,2-a]哒嗪-2,1,3(3H)-三基])四(N-[(1S)-1-苯乙基])苯甲酰胺
• IUPAC name: 2-[(1S,3S)-2-{2-[(1S,3S)-5,8-dioxo-1,3-bis(2-{[(1S)-1-phenylethyl]carbamoyl}phenyl)-hexahydro-1H-[1,2,4]diazaphospholo[1,2-a]pyridazin-2-yl]phenyl}-5,8-dioxo-3-(2-{[(1S)-1-phenylethyl]carbamoyl}phenyl)-hexahydro-1H-[1,2,4]diazaphospholo[1,2-a]pyridazin-1-yl]-N-[(1S)-1-phenylethyl]benzamide
• IUPAC Traditional name: 2-[(1S,3S)-2-{2-[(1S,3S)-5,8-dioxo-1,3-bis(2-{[(1S)-1-phenylethyl]carbamoyl}phenyl)-tetrahydro-[1,2,4]diazaphospholo[1,2-a]pyridazin-2-yl]phenyl}-5,8-dioxo-3-(2-{[(1S)-1-phenylethyl]carbamoyl}phenyl)-tetrahydro-[1,2,4]diazaphospholo[1,2-a]pyridazin-1-yl]-N-[(1S)-1-phenylethyl]benzamide
• Synonyms: Bis[(S,S,S)-DiazaPhos-SPE]; 2,2′,2″,2′′′-(1,2-Phenylenebis[(1S,3S)-tetrahydro-5,8-dioxo-1H-[1,2,4]diazaphospholo[1,2-a]pyridazine-2,1,3(3H)-triyl])tetrakis(N-[(1S)-1-phenylethyl])benzamide

DATABASE IDS

• MDL Number: MFCD10566996
• CAS Number: 851770-14-4

PROPERTIES

• Empirical Formula (Hill Notation): C78H72N8O8P2
• Melting Point: 289-299 °C
• Optical Rotation: [α]20/D +15.0°, c = 1 in THF

DETAILS

Description (English)

Application
Diazaphospholane ligands display excellent levels of conversion and selectivity in Rh-catalyzed asymmetric hydroformylation reactions.7,8
Diazaphospholane Ligands for Catalytic Asymmetric TransformationsCatalytic chiral bisdiazaphospholane ligand used for:
• Enantioselective synthesis of α,β-unsaturated aldehydes via hydroformylation of dienes catalyzed by rhodium catalyst1
• Stereoselective preparation of chiral aldehydes via rhodium-catalyzed enantioselective hydroformylation of N-vinyl carboxamides, allyl ethers, and allyl carbamates2
• Regioselective and enantioselective rhodium-catalyzed hydroformylation of styrene with (S,S,S)-bisdiazaphos3
• Regioselective and enantioselective hydroformylation of dialkyl acrylamides4
• Highly enantioselective hydroformylation of aryl alkenes5
• Styrene hydroformylation reactions catalyzed by rhodium(I) complexes of bis(phosphite) ligands6
Packaging
1 g in glass bottle
500 mg in glass bottle
Legal Information
Product is sold for R&D purpose only and use by end user in the manufacture of products of commerce is not permitted. Product is sold in association with DowpharmaSM a business unit of The Dow Chemical Company. U.S. Pat. 7,071,357B.

Description (简体中文)

Application
二氮杂磷杂环戊烷配体在 Rh-催化的不对称氢甲酰化反应中显示出优良的转化水平和选择性。7,8
Diazaphospholane Ligands for Catalytic Asymmetric TransformationsCatalytic chiral bisdiazaphospholane ligand used for:
• Enantioselective synthesis of α,β-unsaturated aldehydes via hydroformylation of dienes catalyzed by rhodium catalyst1
• Stereoselective preparation of chiral aldehydes via rhodium-catalyzed enantioselective hydroformylation of N-vinyl carboxamides, allyl ethers, and allyl carbamates2
• Regioselective and enantioselective rhodium-catalyzed hydroformylation of styrene with (S,S,S)-bisdiazaphos3
• Regioselective and enantioselective hydroformylation of dialkyl acrylamides4
• Highly enantioselective hydroformylation of aryl alkenes5
• Styrene hydroformylation reactions catalyzed by rhodium(I) complexes of bis(phosphite) ligands6
包装
1 g in glass bottle
500 mg in glass bottle
Legal Information
产品的销售仅限于 R&D 目的并且不允许最终用户在商业产品生产中使用。与 DowpharmaSM（Dow Chemical Company 的业务单位）联合销售产品。美国专利7,071,357B。