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1,1-Dimethylbiguanide hydrochloride_Molecular_structure_CAS_1115-70-4)
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1,1-Dimethylbiguanide hydrochloride

Catalog No. D150959 Name Sigma Aldrich
CAS Number 1115-70-4 Website http://www.sigmaaldrich.com
M. F. C4H12ClN5 Telephone 1-800-521-8956
M. W. 165.62458 Fax
Purity 97% Email
Storage Chembase ID: 72826

SYNONYMS

Title
甲福明 盐酸盐
IUPAC name
1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
IUPAC Traditional name
metformin hydrochloride
Synonyms
二甲双胍
Metformin

DATABASE IDS

MDL Number MFCD00012582
PubChem SID 24893460
EC Number 214-230-6
CAS Number 1115-70-4

PROPERTIES

Linear Formula NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
Purity 97%
Melting Point 223-226 °C(lit.)
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P305 + P351 + P338
Risk Statements 22-36/38
RTECS DU1800000
Safety Statements 26-36
German water hazard class 3

DETAILS

Description (English)
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.
Packaging
5 g in glass bottle
Description (简体中文)
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
甲福明是一种抗糖尿病药,可降低血糖水平,提高胰岛素灵敏度。其代谢作用(包括抑制肝脏糖异生作用)至少部分是通过激活 LKB1-AMPK(AMP-活化蛋白激酶)通路进行介导。该通路的激活也涉及到癌细胞系中甲福明的抗增殖和促凋亡作用。
包装
5 g in glass bottle

REFERENCES