Tamoxifen

• Catalog No.: 281611
• CAS Number: 10540-29-1
• M. F.: C26H29NO
• M. W.: 371.51456
• Purity: 96%

SYNONYMS

• Title: 他莫昔芬
• IUPAC name: {2-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]ethyl}dimethylamine
• IUPAC Traditional name: {2-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]ethyl}dimethylamine
• Synonyms: (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene; trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; (Z)-1-(对二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯; (Z)-2-[4-(1,2-二苯基-1-丁烯)苯氧基]-N,N-二甲基乙胺

DATABASE IDS

• CAS Number: 10540-29-1
• MDL Number: MFCD00010454
• EC Number: 234-118-0

PROPERTIES

• Linear Formula: C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2
• Purity: 96%
• Gene Information: human ... ESR1(2099)
• Melting Point: 97-98 °C(lit.)
• GHS Signal Word: Danger
• GHS Hazard statements: H350-H360-H362
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P263-P308 + P313
• Risk Statements: 45-60-61-64
• RTECS: KR5919600
• Safety Statements: 53-45
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

Description (简体中文)

Biochem/physiol Actions
蛋白激酶 C 抑制剂。诱发人类恶性神经胶质瘤细胞系的细胞凋亡。他莫昔芬及其代谢产物 4-羟基他莫昔芬是选择性雌激素反应调节剂 (SERM)，在乳腺中用作雌激素拮抗剂。阻止乳腺肿瘤细胞中雌二醇刺激的 VEGF 的产生。